We are interested in the structure and function of ion channels at the molecular level. These membrane proteins control the flux of ions across cell membranes and play important roles in muscle contraction, nerve impulse, secretion and more. We study both human and insect ion channels with the aim to understand their molecular mechanism and develop therapeutic and insecticidal molecules. The research in the Yuchi lab takes a multi-disciplinary approach, including structural biology, biophysics, chemical biology, and computational biology.
We employ two major structural biology methods: x-ray crystallography and cryo-electron microscopy.
We use the super-computer centre located in TJU to do high-throughput drug screening and protein modelling.
We combine fluorescence-based drug screening with stucture-based drug design (SBDD) and fragment-based drug design (FBDD).
Ion channel-targeted drug/insecticide development