Oct 20th, 2024
PAPER ON RYR AND DIAMIDE INSECTICIDES OUT IN NATURE COMMUNICATIONS
Using a chimeric RyR approach and cryo-EM, we investigate how insect RyRs engage two different diamide insecticides from separate families. Our findings elucidate the mode of action of different diamide insecticides, reveal the molecular mechanism of resistance mutations. This is a collaborative endeavour with Prof. Filip Van Petegem’s team from UBC.
News links:
https://mp.weixin.qq.com/s/QJ1z91am03EGVNU6nPMYiQ
https://www.tju.edu.cn/english/info/1010/8414.htm
Aug 27th, 2023
Funded by National Natural Science Foundation of China (NSFC)
Our group is newly funded by NSFC on the study of sodium channel!
Mar 22nd, 2022
PAPER ON DILATED CARDIOMYOPATHY (DCM) PUBLISHED IN eLIFE
Our new crystal structures of protein kinase A (PKA) in complex with wild type and DCM mutant phospholamban (PLN) has been published in eLife. It reveals a common mechanism for familial dilated cardiomyopathy. This work is led by PhD student Juan Qin with a team effort from PhD student Lianyun Lin and collaborators from CAS, TJU, and UBC.
News links:
https://mp.weixin.qq.com/s/Hbcs91iFWopo9eCuMF1NcA
http://news.tju.edu.cn/info/1012/60543.htm
http://www.tju.edu.cn/english/info/1010/6010.htm
Nov 12th, 2021
CONGRATULATE RUIFANG MA
Big congratulations to Ruifang for winning the best PhD thesis award of Tianjin University in 2021!
News links:
https://mp.weixin.qq.com/s/X1o1OUmcyOY71hfXqfDHcA
Oct 19th, 2021
PAPER ON COVID-19 RESEARCH PUBLISHED IN FEBS J
Our study on SARS-Cov-2 nucleocapsid protein and its targeting nanobodies has been published in FEBS journal. Thanks Chen, Yuewen, Heng, Zijing, and Jialu for their heroic work during the pandemic!
Aug 18th, 2020
PAPER ON MOA OF DIAMIDE INSECTICIDES OUT IN NATURE CHEMICAL BIOLOGY
Our new cyro-EM structure of RyR-chlorantraniliprole complex has been published in Nature Chemical Biology. It reveals the binding mode and resistance mechanism of the top-selling diamide insecticides. This is a great teamwork achievement by scientists from China, Canada, Japan, Germany, and the Netherland.
News links:
http://tju.edu.cn/info/1026/3391.htm
https://mp.weixin.qq.com/s/a9C4suV00KEdNrZFZ4mlAQ
http://health.tju.edu.cn/info/1084/1591.htm
May 9th, 2020
PAPER ON DIAMONDBACK MOTH OUT IN NATURE COMMUNICATIONS
Our collaborated study with Prof. You’s group from FAFU on the genome and evolution of diamondback moth has been published in Nature Communications.
News links:
Apr 2nd, 2020
TWO NEW PAPERS OUT IN JAFC AND SELECTED AS ACS EDITOR’S CHOICE
Our recent two papers on dimondback moth RyR, led by master students Yuanyuan Zhou and Arthur Samurkas, have been published in the Journal of Agricultural and Food Chemistry, and selected as American Chemical Society (ACS) editor’s choice .
News links:
http://www.tju.edu.cn/english/info/1010/4931.htm
http://news.tju.edu.cn/info/1012/50757.htm
https://mp.weixin.qq.com/s/U4Pgz1466vmhVFdJ5_8BCQ
Oct 31th, 2019
INSECT RYR PAPERS OUT IN BMC BIOLOGY AND PMS
Our recent two studies on the crystal structure of insect RyR phosphorylation domain and modelling of insect RyR led by master student Tong Xu and PhD students Lianyun Lin and Zhiyuan Hao have been published in BMC Biology and PMS. TJU website reports our discovery in green pesticide development.
News links:
May 14th, 2019
CONGRATULATE JUAN QIN AND JIE WANG
Big congratulations to Juan and Jie for successfully defending their master thesis today! They are the first ever Master students to graduate from the Yuchi lab. Juan will stay with us for Ph.D study and Jie will work for Tianjin government. We wish both of them all the best for the new pages of their life!
May 11th, 2019
PAPER ON RYR PHOSPHORYLATION OUT IN MOLECULAR CELL
Our collaborated study with Prof. Van Petegem’s group from UBC on the phosphorylation regulation on the cardiac ryanodine receptor has been published in Molecular Cell.
News links:
Apr 9th, 2019
GUT BACTERIA PAPER OUT IN NATURE COMMUNICATIONS
We collaborated with Zhang group to solve the puzzle of C-S bond cleavage in gut bacteria. The result has been published in Nature Communications.
News links:
http://www.tju.edu.cn/english/info/1011/4129.htm
http://news.tju.edu.cn/info/1012/44391.htm
June 27th, 2017
SUDDEN CARDIAC DEATH OF AN ATHLETE IN BEIJING FOOTBALL CLUB RELATED TO OUR RESEARCH
Our collaborated multicenter clinical study about sudden death in athletes is highlighted on TJU website.
News links:
http://www.tju.edu.cn/english/info/1011/4020.htm